Targeting the ACE2 and Apelin Pathways Are Novel Therapies for Heart Failure: Opportunities and Challenges

Angiotensin-converting enzyme 2 (ACE2)/Ang II/Ang 1–7 and the apelin/APJ are two important peptide systems which exert diverse effects on the cardiovascular system. ACE2 is a key negative regulator of the renin-angiotensin system (RAS) where it metabolizes angiotensin (Ang) II into Ang 1–7, an endog...

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Bibliografiske detaljer
Main Authors: Kazemi-Bajestani, Seyyed M. R., Patel, Vaibhav B., Wang, Wang, Oudit, Gavin Y.
Format: Artigo
Sprog:Inglês
Udgivet: Hindawi Publishing Corporation 2012
Fag:
Review Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359660/
https://ncbi.nlm.nih.gov/pubmed/22655211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/823193
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