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Identification of Critical Residues Involved in Ligand Binding and G Protein Signaling in Human Somatostatin Receptor Subtype 2

G protein signaling through human somatostatin receptor subtype 2 (SSTR2) is well known, but the amino acids involved in stimulation of intracellular responses upon ligand binding have not been characterized. We constructed a series of point mutants in SSTR2 at amino acid positions 89, 139, and 140...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Parry, Jesse J., Chen, Ronald, Andrews, Rebecca, Lears, Kimberly A., Rogers, Buck E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Endocrine Society 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359596/
https://ncbi.nlm.nih.gov/pubmed/22495673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1662
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