Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets

BACKGROUND: Protein structures provide a valuable resource for rational drug design. For a protein with no known ligand, computational tools can predict surface pockets that are of suitable size and shape to accommodate a complementary small-molecule drug. However, pocket prediction against single s...

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Bibliographic Details
Main Authors: Ashford, Paul, Moss, David S, Alex, Alexander, Yeap, Siew K, Povia, Alice, Nobeli, Irene, Williams, Mark A
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
Subjects:
Methodology Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359218/
https://ncbi.nlm.nih.gov/pubmed/22417279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-39
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