Visualisation of variable binding pockets on protein surfaces by probabilistic analysis of related structure sets

BACKGROUND: Protein structures provide a valuable resource for rational drug design. For a protein with no known ligand, computational tools can predict surface pockets that are of suitable size and shape to accommodate a complementary small-molecule drug. However, pocket prediction against single s...

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Библиографические подробности
Главные авторы: Ashford, Paul, Moss, David S, Alex, Alexander, Yeap, Siew K, Povia, Alice, Nobeli, Irene, Williams, Mark A
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2012
Предметы:
Methodology Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3359218/
https://ncbi.nlm.nih.gov/pubmed/22417279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-13-39
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