PARK2 variability in Polish Parkinson’s disease patients - interaction with mitochondrial haplogroups

AIMS AND OBJECTIVES: A new pathomechanism of Parkinson’s disease (PD) involving regulation of mitochondrial functions was recently proposed. Parkin complexed with mitochondrial transcription factor A (TFAM) binds mtDNA and promotes mitochondrial biogenesis, which is abolished by PARK2 gene mutations...

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Hauptverfasser: Gaweda-Walerych, Katarzyna, Safranow, Krzysztof, Jasinska-Myga, Barbara, Bialecka, Monika, Klodowska-Duda, Gabriela, Rudzinska, Monika, Czyzewski, Krzysztof, Cobb, Stephanie A., Slawek, Jaroslaw, Styczynska, Maria, Opala, Grzegorz, Drozdzik, Marek, Nishioka, Kenya, Farrer, Matthew J, Ross, Owen A, Wszolek, Zbigniew K, Barcikowska, Maria, Zekanowski, Cezary
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358581/
https://ncbi.nlm.nih.gov/pubmed/22361577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.parkreldis.2012.01.021
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