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Rottlerin increases cardiac contractile performance and coronary perfusion through BK(Ca++) channel activation following cold cardioplegic arrest in isolated hearts

BACKGROUND: Cardioplegia and cardiopulmonary bypass(CP/CPB) subjects myocardium to complex injurious stimuli that can result in cardiomyocyte and vascular contractile abnormalities. Rottlerin, originally identified as a PKCδ inhibitor has a number of known additional effects that may be beneficial i...

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Bibliografski detalji
Glavni autori: Clements, Richard T, Cordeiro, Brenda, Feng, Jun, Bianchi, Cesario, Sellke, Frank W.
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358121/
https://ncbi.nlm.nih.gov/pubmed/21911819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.012112
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