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Rottlerin increases cardiac contractile performance and coronary perfusion through BK(Ca++) channel activation following cold cardioplegic arrest in isolated hearts
BACKGROUND: Cardioplegia and cardiopulmonary bypass(CP/CPB) subjects myocardium to complex injurious stimuli that can result in cardiomyocyte and vascular contractile abnormalities. Rottlerin, originally identified as a PKCδ inhibitor has a number of known additional effects that may be beneficial i...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3358121/ https://ncbi.nlm.nih.gov/pubmed/21911819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.012112 |
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