Suppression of human breast tumors in NOD/SCID mice by CD44 shRNA gene therapy combined with doxorubicin treatment

BACKGROUND: Breast cancer stem cells with a CD44(+)CD24(−) phenotype are the origin of breast tumors. Strong CD44 expression in this population indicates its important role in maintaining the stem cell phenotype. Previous studies show that CD44 down-regulation causes CD44(+)CD24(−) breast cancer ste...

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Detalhes bibliográficos
Main Authors: Van Pham, Phuc, Vu, Ngoc Bich, Duong, Thuy Thanh, Nguyen, Tam Thanh, Truong, Nhung Hai, Phan, Nhan Lu Chinh, Vuong, Tue Gia, Pham, Viet Quoc, Nguyen, Hoang Minh, Nguyen, Kha The, Nguyen, Nhung Thi, Nguyen, Khue Gia, Khat, Lam Tan, Van Le, Dong, Truong, Kiet Dinh, Phan, Ngoc Kim
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2012
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Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358118/
https://ncbi.nlm.nih.gov/pubmed/22649280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S30609
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