Wig-1, a novel regulator of N-Myc mRNA and N-Myc-driven tumor growth

Wig-1 is a transcriptional target of the p53 tumor suppressor and encodes an mRNA stability-regulating protein. We show here that Wig-1 knockdown causes a dramatic inhibition of N-Myc expression and triggers differentiation in neuroblastoma cells carrying amplified N-Myc. Transient Wig-1 knockdown s...

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Detalhes bibliográficos
Main Authors: Vilborg, A, Bersani, C, Wickström, M, Segerström, L, Kogner, P, Wiman, K G
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3358011/
https://ncbi.nlm.nih.gov/pubmed/22513872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2012.33
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