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Downregulation of the transcription factor KLF4 is required for the lineage commitment of T cells
The roles of the reprogramming factors Oct4, Sox2, c-Myc and Klf4 in early T cell development are incompletely defined. Here, we show that Klf4 is the only reprogramming factor whose expression is downregulated when early thymic progenitors (ETPs) differentiate into T cells. Enforced expression of K...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3357995/ https://ncbi.nlm.nih.gov/pubmed/22105482 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.183 |
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