α1-Acid Glycoprotein Decreases Neutrophil Migration and Increases Susceptibility to Sepsis in Diabetic Mice

The mechanisms underlying immune deficiency in diabetes are largely unknown. In the present study, we demonstrate that diabetic mice are highly susceptible to polymicrobial sepsis due to reduction in rolling, adhesion, and migration of leukocytes to the focus of infection. In addition, after sepsis...

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Detalhes bibliográficos
Main Authors: Spiller, Fernando, Carlos, Daniela, Souto, Fabrício O., de Freitas, Andressa, Soares, Fernanda S., Vieira, Silvio M., Paula, Francisco J.A., Alves-Filho, José C., Cunha, Fernando Q.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2012
Assuntos:
Complications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357278/
https://ncbi.nlm.nih.gov/pubmed/22415874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db11-0825
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