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Phosphorylated acidic serine–aspartate-rich MEPE-associated motif peptide from matrix extracellular phosphoglycoprotein inhibits phosphate regulating gene with homologies to endopeptidases on the X-chromosome enzyme activity

Inactivating PHEX (phosphate regulating gene with homologies to endopeptidases on the X chromosome) mutations cause X-linked hypophosphatemia in humans and mice (Hyp) through overproduction of fibroblast growth factor 23 (FGF23) a phosphaturic factor, by osteocytes. Matrix extracellular phosphoglyco...

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Bibliografiske detaljer
Main Authors: Liu, Shiguang, Rowe, Peter S N, Vierthaler, Luke, Zhou, Jianping, Quarles, L Darryl
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3357085/
https://ncbi.nlm.nih.gov/pubmed/17210763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1677/joe.1.07059
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