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Nucleotide-dependent mechanism of Get3 as elucidated from free energy calculations

The unique topology of tail-anchored (TA) proteins precludes them from utilizing the well-studied cotranslational translocation mechanism of most transmembrane proteins, forcing them into a distinct, posttranslational pathway. In yeast, this process is the guided entry of TA-proteins (GET) pathway,...

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Main Authors: Wereszczynski, Jeff, McCammon, J. Andrew
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2012
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356667/
https://ncbi.nlm.nih.gov/pubmed/22547793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117441109
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