Apoptotic marginal zone deletion of anti-Sm/ribonucleoprotein B cells

CD40L is excessively produced in both human and murine lupus and plays a role in lupus pathogenesis. To address how excess CD40L induces autoantibody production, we crossed CD40L-transgenic mice with the anti-DNA H-chain transgenic mouse lines 3H9 and 56R, well-characterized models for studying B-ce...

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Detalhes bibliográficos
Main Authors: Kishi, Yusuke, Higuchi, Tetsuya, Phoon, Shirly, Sakamaki, Yasuo, Kamiya, Koki, Riemekasten, Gabriela, Akiyoshi, Kazunari, Weigert, Martin G., Tsubata, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356631/
https://ncbi.nlm.nih.gov/pubmed/22547827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1204509109
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