Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons

The time course of signaling via heterotrimeric G proteins is controlled through their activation by G-protein coupled receptors and deactivation through the action of GTPase accelerating proteins (GAPs). Here we identify RGS7 and RGS11 as the key GAPs in the mGluR6 pathway of retinal rod ON bipolar...

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Bibliografiska uppgifter
Huvudupphovsmän: Cao, Yan, Pahlberg, Johan, Sarria, Ignacio, Kamasawa, Naomi, Sampath, Alapakkam P., Martemyanov, Kirill A.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356620/
https://ncbi.nlm.nih.gov/pubmed/22547806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1202332109
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