Pharmacokinetics, tissue distribution, and metabolites of a polyvinylpyrrolidone-coated norcantharidin chitosan nanoparticle formulation in rats and mice, using LC-MS/MS

A novel formulation containing polyvinylpyrrolidone (PVP) K(30)-coated norcantharidin (NCTD) chitosan nanoparticles (PVP–NCTD–NPs) was prepared by ionic gelation between chitosan and sodium tripolyphosphate. The average particle size of the PVP–NCTD–NPs produced was 140.03 ± 6.23 nm; entrapment effi...

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Detalhes bibliográficos
Main Authors: Ding, Xin-Yuan, Hong, Cheng-Jiao, Liu, Yang, Gu, Zong-Lin, Xing, Kong-Lang, Zhu, Ai-Jun, Chen, Wei-Liang, Shi, Lin-Seng, Zhang, Xue-Nong, Zhang, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2012
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3356170/
https://ncbi.nlm.nih.gov/pubmed/22619523
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S29696
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