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The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer
The function of tumor suppressor VHL is compromised in the vast majority of clear cell renal cell carcinoma, and its mutations or loss of expression was causal for this disease. pVHL was found to be a substrate recognition subunit of an E3 ubiquitin ligase, and most of the tumor-derived mutations di...
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| Главные авторы: | , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Frontiers Research Foundation
2012
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3355907/ https://ncbi.nlm.nih.gov/pubmed/22649785 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2012.00035 |
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