Peroxisome Proliferator-Activated Receptor γ Decouples Fatty Acid Uptake from Lipid Inhibition of Insulin Signaling in Skeletal Muscle

Peroxisome proliferator-activated receptor γ (PPARγ) is expressed at low levels in skeletal muscle, where it protects against adiposity and insulin resistance via unclear mechanisms. To test the hypothesis that PPARγ directly modulates skeletal muscle metabolism, we created two models that isolate d...

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Bibliographic Details
Main Authors: Hu, Shanming, Yao, Jianrong, Howe, Alexander A., Menke, Brandon M., Sivitz, William I., Spector, Arthur A., Norris, Andrew W.
Format: Artigo
Language:Inglês
Published: Endocrine Society 2012
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355543/
https://ncbi.nlm.nih.gov/pubmed/22474127
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2011-1253
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