B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas

We show that microRNA-21 is significantly elevated in peripheral B cells of HIV infected individuals who go on to develop AIDS-NHL (n=13, < 3 yrs prior to diagnosis) when compared to HIV negative (n = 18) or HIV positive controls (n = 21) (p < 0.01). Moreover, miR-21 is overex-pressed in activ...

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Autors principals: Thapa, Dharma R., Bhatia, Kishor, Bream, Jay H., D'souza, Gypsyamber, Rinaldo, Charles R., Wolinsky, Steven, Detels, Roger, Martinez-Maza, Otoniel
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355225/
https://ncbi.nlm.nih.gov/pubmed/22487708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/QAD.0b013e3283543e0e
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