Mutations in ASXL1 are associated with poor prognosis across the spectrum of malignant myeloid diseases

The ASXL1 gene is one of the most frequently mutated genes in malignant myeloid diseases. The ASXL1 protein belongs to protein complexes involved in the epigenetic regulation of gene expression. ASXL1 mutations are found in myeloproliferative neoplasms (MPN), myelodysplastic syndromes (MDS), chronic...

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Détails bibliographiques
Auteurs principaux: Gelsi-Boyer, Véronique, Brecqueville, Mandy, Devillier, Raynier, Murati, Anne, Mozziconacci, Marie-Joelle, Birnbaum, Daniel
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2012
Sujets:
Review
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3355025/
https://ncbi.nlm.nih.gov/pubmed/22436456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-8722-5-12
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