The use of Next Generation Sequencing Technology to Study the Effect of Radiation Therapy on Mitochondrial DNA Mutation

The human mitochondrial genome has an exclusively maternal mode of inheritance. Mitochondrial DNA (mtDNA) is particularly vulnerable to environmental insults due in part to an underdeveloped DNA repair system, limited to base excision and homologous recombination repair. Radiation exposure to the ov...

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Hlavní autoři: Guo, Yan, Cai, Qiuyin, Samuels, David C., Ye, Fei, Long, Jirong, Li, Chung-I, Winther, Jeanette F., Tawn, E. Janet, Stovall, Marilyn, Lähteenmäki, Päivi, Malia, Nea, Levy, Shawn, Shaffer, Christian, Shyr, Yu, Shu, Xiao-ou, Boice, John D.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2012
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354959/
https://ncbi.nlm.nih.gov/pubmed/22387842
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2012.02.006
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