Enhanced activity of punicalagin delivered via polymeric implants against benzo[a]pyrene-induced DNA adducts

We investigated the effect of punicalagin (PC) on benzo[a]pyrene (BP)-induced DNA adducts in vitro and in vivo. Incubation of BP (1 μM) with rat liver microsomes, appropriate co-factors and DNA in the presence of vehicle or punicalagin (1–40 μM) showed dose-dependent inhibition of the resultant DNA...

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Main Authors: Aqil, Farrukh, Vadhanam, Manicka V., Gupta, Ramesh
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354568/
https://ncbi.nlm.nih.gov/pubmed/22234049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mrgentox.2011.12.022
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