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Metal-Free Catalytic Enantioselective C–B Bond Formation: (Pinacolato)boron Conjugate Additions to α,β-Unsaturated Ketones, Esters, Weinreb Amides and Aldehydes Promoted by Chiral N-Heterocyclic Carbenes

The first broadly applicable metal-free enantioselective method for boron conjugate addition (BCA) to α,β-unsaturated carbonyls is presented. The C–B bond forming reactions are promoted in the presence of 2.5–7.5 mol % of a readily accessible C(1)-symmetric chiral imidazolinium salt, which is conver...

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Bibliografiske detaljer
Main Authors: Wu, Hao, Radomkit, Suttipol, O’Brien, Jeannette M., Hoveyda, Amir H.
Format: Artigo
Sprog:Inglês
Udgivet: 2012
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3354020/
https://ncbi.nlm.nih.gov/pubmed/22559866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja302929d
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