The Loss of Functional Caspase-12 in Europe Is a Pre-Neolithic Event

BACKGROUND: Caspase-12 (CASP12) modulates the susceptibility to sepsis. In humans, the “C” allele at CASP12 rs497116 has been associated with an increased risk of sepsis. Instead, the derived “T” allele encodes for an inactive caspase-12. Interestingly, Eurasians are practically fixed for the inacti...

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Main Authors: Hervella, Montserrat, Plantinga, Theo S., Alonso, Santos, Ferwerda, Bart, Izagirre, Neskuts, Fontecha, Lara, Fregel, Rosa, van der Meer, Jos W. M., de-la-Rúa, Concepcion, Netea, Mihai G.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353979/
https://ncbi.nlm.nih.gov/pubmed/22615879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037022
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