K65R in Subtype C HIV-1 Isolates from Patients Failing on a First-Line Regimen Including d4T or AZT: Comparison of Sanger and UDP Sequencing Data

BACKGROUND: We and others have shown that subtype C HIV-1 isolates from patients failing on a regimen containing stavudine (d4T) or zidovudine (AZT) exhibit thymidine-associated mutations (TAMs) and K65R which can impair the efficacy of Tenofovir (TDF) at second line. Depending on the various studie...

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Main Authors: Recordon-Pinson, Patricia, Papuchon, Jennifer, Reigadas, Sandrine, Deshpande, Alaka, Fleury, Hervé
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353948/
https://ncbi.nlm.nih.gov/pubmed/22615779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036549
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