Clinical Severity of β-thalassaemia/Hb E Disease Is Associated with Differential Activities of the Calpain-Calpastatin Proteolytic System

Earlier observations in the literature suggest that proteolytic degradation of excess unmatched α-globin chains reduces their accumulation and precipitation in β-thalassaemia erythroid precursor cells and have linked this proteolytic degradation to the activity of calpain protease. The aim of this s...

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Bibliografiske detaljer
Main Authors: Sukati, Suriyan, Svasti, Saovaros, Stifanese, Roberto, Averna, Monica, Panutdaporn, Nantika, Penglong, Tipparat, Melloni, Edon, Fucharoen, Suthat, Katzenmeier, Gerd
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3353910/
https://ncbi.nlm.nih.gov/pubmed/22615919
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0037133
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