Pyrrole-Based Antitubulin Agents: Two Distinct Binding Modalities Are Predicted for C-2 Analogues in the Colchicine Site

[Image: see text] 3,5-Dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester is a promising antitubulin lead agent that targets the colchicine site of tubulin. C-2 analogues were synthesized and tested for microtubule depolymerizing and antiproliferative activity. Molecular modelin...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Da, Chenxiao, Telang, Nakul, Barelli, Peter, Jia, Xin, Gupton, John T., Mooberry, Susan L., Kellogg, Glen E.
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2011
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352664/
https://ncbi.nlm.nih.gov/pubmed/22611477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml200217u
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares