Comparison of growth factor signalling pathway utilisation in cultured normal melanocytes and melanoma cell lines

BACKGROUND: The phosphatidylinositol-3-kinase (PI3K-PKB), mitogen activated protein kinase (MEK-ERK) and the mammalian target of rapamycin (mTOR- p70S6K), are thought to regulate many aspects of tumour cell proliferation and survival. We have examined the utilisation of these three signalling pathwa...

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Bibliografiske detaljer
Main Authors: Kim, Ji Eun, Stones, Clare, Joseph, Wayne R, Leung, Euphemia, Finlay, Graeme J, Shelling, Andrew N, Phillips, Wayne A, Shepherd, Peter R, Baguley, Bruce C
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2012
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3352269/
https://ncbi.nlm.nih.gov/pubmed/22475322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-12-141
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