APP physiological and pathophysiological functions: insights from animal models

The amyloid precursor protein (APP) has been under intensive study in recent years, mainly due to its critical role in the pathogenesis of Alzheimer's disease (AD). β-Amyloid (Aβ) peptides generated from APP proteolytic cleavage can aggregate, leading to plaque formation in human AD brains. Poi...

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Detaylı Bibliyografya
Asıl Yazarlar: Guo, Qinxi, Wang, Zilai, Li, Hongmei, Wiese, Mary, Zheng, Hui
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2012
Konular:
Review
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351924/
https://ncbi.nlm.nih.gov/pubmed/21769132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cr.2011.116
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