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Suppression of endogenous PPARγ increases vulnerability to methamphetamine –induced injury in mouse nigrostriatal dopaminergic pathway

RATIONALE: Methamphetamine is a commonly abused drug and dopaminergic neurotoxin. Repeated administration of high doses of methamphetamine induces programmed cell death, suppression of dopamine release, and reduction in locomotor activity. Previous studies have shown that pretreatment with Peroxisom...

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Hlavní autoři: Yu, Seong-Jin, Airavaara, Mikko, Shen, Hui, Chou, Jenny, Harvey, Brandon K., Wang, Yun
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351577/
https://ncbi.nlm.nih.gov/pubmed/22160138
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00213-011-2595-7
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