Innate Immune Response of Human Plasmacytoid Dendritic Cells to Poxvirus Infection Is Subverted by Vaccinia E3 via Its Z-DNA/RNA Binding Domain

Plasmacytoid dendritic cells (pDCs) play important roles in antiviral innate immunity by producing type I interferon (IFN). In this study, we assess the immune responses of primary human pDCs to two poxviruses, vaccinia and myxoma virus. Vaccinia, an orthopoxvirus, was used for immunization against...

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Bibliographic Details
Main Authors: Cao, Hua, Dai, Peihong, Wang, Weiyi, Li, Hao, Yuan, Jianda, Wang, Fangjin, Fang, Chee-Mun, Pitha, Paula M, Liu, Jia, Condit, Richard C, McFadden, Grant, Merghoub, Taha, Houghton, Alan N, Young, James W, Shuman, Stewart, Deng, Liang
Format: Artigo
Language:Inglês
Published: Public Library of Science 2012
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351467/
https://ncbi.nlm.nih.gov/pubmed/22606294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0036823
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