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A negative regulatory element in the promoter of the human alpha 1-antitrypsin gene.

A "minimal tissue-specific element" of the human alpha 1-antitrypsin (alpha 1-AT) gene promoter, located in the -137/-37 region, is able to drive hepatoma-specific transcription from the heterologous SV40 promoter. Here we show that, in HeLa cells, this element is inactivated by a negative...

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Bibliografiske detaljer
Main Authors: De Simone, V, Cortese, R
Format: Artigo
Sprog:Inglês
Udgivet: 1989
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC335141/
https://ncbi.nlm.nih.gov/pubmed/2555792
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