Opiate Antagonist Prevents μ- and δ-Opiate Receptor Dimerization to Facilitate Ability of Agonist to Control Ethanol-altered Natural Killer Cell Functions and Mammary Tumor Growth

In the natural killer (NK) cells, δ-opiate receptor (DOR) and μ-opioid receptor (MOR) interact in a feedback manner to regulate cytolytic function with an unknown mechanism. Using RNK16 cells, a rat NK cell line, we show that MOR and DOR monomer and dimer proteins existed in these cells and that chr...

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Autors principals: Sarkar, Dipak K., Sengupta, Amitabha, Zhang, Changqing, Boyadjieva, Nadka, Murugan, Sengottuvelan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2012
Matèries:
Signal Transduction
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351352/
https://ncbi.nlm.nih.gov/pubmed/22451667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.347583
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