Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema: IMPLICATION OF ABERRANT TRANSFORMING GROWTH FACTOR-β SIGNALING AND MATRIX METALLOPROTEINASE GENE EXPRESSION

We previously demonstrated that a deficiency in core fucosylation caused by the genetic disruption of α1,6-fucosyltransferase (Fut8) leads to lethal abnormalities and the development of emphysematous lesions in the lung by attenuation of TGF-β1 receptor signaling. Herein, we investigated the physiol...

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Bibliographische Detailangaben
Hauptverfasser: Gao, Congxiao, Maeno, Toshitaka, Ota, Fumi, Ueno, Manabu, Korekane, Hiroaki, Takamatsu, Shinji, Shirato, Ken, Matsumoto, Akio, Kobayashi, Satoshi, Yoshida, Keiichi, Kitazume, Shinobu, Ohtsubo, Kazuaki, Betsuyaku, Tomoko, Taniguchi, Naoyuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2012
Schlagworte:
Glycobiology and Extracellular Matrices
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351343/
https://ncbi.nlm.nih.gov/pubmed/22433854
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.315333
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