Human Cyclin-dependent Kinase 2-associated Protein 1 (CDK2AP1) Is Dimeric in Its Disulfide-reduced State, with Natively Disordered N-terminal Region

CDK2AP1 (cyclin-dependent kinase 2-associated protein 1), corresponding to the gene doc-1 (deleted in oral cancer 1), is a tumor suppressor protein. The doc-1 gene is absent or down-regulated in hamster oral cancer cells and in many other cancer cell types. The ubiquitously expressed CDK2AP1 protein...

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Detalhes bibliográficos
Main Authors: Ertekin, Asli, Aramini, James M., Rossi, Paolo, Leonard, Paul G., Janjua, Haleema, Xiao, Rong, Maglaqui, Melissa, Lee, Hsiau-Wei, Prestegard, James H., Montelione, Gaetano T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351331/
https://ncbi.nlm.nih.gov/pubmed/22427660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.343863
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