Activated Protein C Inhibits Pancreatic Islet Inflammation, Stimulates T Regulatory Cells, and Prevents Diabetes in Non-obese Diabetic (NOD) Mice

Activated protein C (aPC) is a natural anticoagulant with strong cyto-protective and anti-inflammatory properties. aPC inhibits pancreatic inflammation and preserves functional islets after intraportal transplantation in mice. Whether aPC prevents the onset or development of type 1 diabetes (T1D) is...

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Main Authors: Xue, Meilang, Dervish, Suat, Harrison, Leonard C., Fulcher, Gregory, Jackson, Christopher J.
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2012
主題:
Immunology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351324/
https://ncbi.nlm.nih.gov/pubmed/22447930
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.325951
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