Structural Factors and Mechanisms Underlying the Improved Photodynamic Cell Killing with Silicon Phthalocyanine Photosensitizers Directed to Lysosomes Versus Mitochondria

The phthalocyanine photosensitizer Pc 4 has been shown to bind preferentially to mitochondrial and endoplasmic reticulum membranes. Upon photoirradiation of Pc 4-loaded cells, membrane components, especially Bcl-2, are photodamaged and apoptosis, as indicated by activation of caspase-3 and cleavage...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Rodriguez, Myriam E., Zhang, Ping, Azizuddin, Kashif, Delos Santos, Grace B., Chiu, Song-mao, Xue, Liang-yan, Berlin, Jeffery C., Peng, Xinzhan, Wu, Hongqiao, Lam, Minh, Nieminen, Anna-Liisa, Kenney, Malcolm E., Oleinick, Nancy L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2009
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3351115/
https://ncbi.nlm.nih.gov/pubmed/19508642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1751-1097.2009.00558.x
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