Efficacy of Phosphatidylinositol-3 Kinase Inhibitors in a Primary Mouse Model of Undifferentiated Pleomorphic Sarcoma

Recent advances in sarcoma genomics have identified novel mutations in the PI3K pathway in human sarcomas. Here, we use a mouse model of primary soft-tissue sarcoma for preclinical testing of doxorubicin and inhibitors of the PI3K pathway: BKM120 (PI3K inhibitor) and BEZ235 (a dual PI3K/mTOR inhibit...

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Autori principali: Kim, Suzy, Dodd, Rebecca D., Mito, Jeffrey K., Ma, Yan, Kim, Yongbaek, Riedel, Richard F., Kirsch, David G.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Hindawi Publishing Corporation 2012
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350993/
https://ncbi.nlm.nih.gov/pubmed/22619567
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/680708
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