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Nutlin-3 induces apoptosis, disrupts viral latency and inhibits expression of angiopoietin-2 in Kaposi sarcoma tumor cells

Kaposi sarcoma (KS) tumors often contain a wild-type p53. However, the function of this tumor suppressor in KS tumor cells is inhibited by both MDM2 and latent nuclear antigen (LANA) of Kaposi sarcoma-associated herpes virus (KSHV). Here, we report that MDM2 antagonist Nutlin-3 efficiently reactivat...

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Bibliografski detalji
Glavni autori: Ye, Fengchun, Lattif, Ali Abdul, Xie, Jianping, Weinberg, Aaron, Gao, Shoujiang
Format: Artigo
Jezik:Inglês
Izdano: Landes Bioscience 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350880/
https://ncbi.nlm.nih.gov/pubmed/22421142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cc.19756
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