Desferrioxamine Attenuates Doxorubicin-Induced Acute Cardiotoxicity through TFG-β/Smad p53 Pathway in Rat Model

Interaction of doxorubicin DOX with iron and the consequent generation of reactive oxygen species (ROS) is a major player in DOX-induced cardiomyopathy. Accordingly, this study has been initiated to investigate the preventive effect of the iron chelator, desferrioxamine (DFX), against DOX-induced ac...

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Detalhes bibliográficos
Main Authors: Al-Shabanah, Othman A., Aleisa, Abdulaziz M., Hafez, Mohamed M., Al-Rejaie, Salim S., Al-Yahya, Abdulaziz A., Bakheet, Saleh A., Al-Harbi, Mohamed M., Sayed-Ahmed, Mohamed M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350848/
https://ncbi.nlm.nih.gov/pubmed/22619697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2012/619185
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