Belimumab Reduces Autoantibodies, Normalizes Low Complement, and Reduces Select B-Cell Populations in Patients With Systemic Lupus Erythematosus

OBJECTIVE: To assess the effects of the B-lymphocyte stimulator (BLyS)-specific inhibitor belimumab on immunologic biomarkers, including B- and T-cell populations, and maintenance of antibody titers to prior vaccines in autoantibody-positive systemic lupus erythematosus (SLE) patients. METHODS: Pool...

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Autors principals: STOHL, WILLIAM, HIEPE, FALK, LATINIS, KEVIN M., THOMAS, MATHEW, SCHEINBERG, MORTON A., CLARKE, ANN, ARANOW, CYNTHIA, WELLBORNE, FRANK R., ABUD-MENDOZA, CARLOS, HOUGH, DOUGLAS R., PINEDA, LILIA, MIGONE, THI-SAU, ZHONG, Z. JOHN, FREIMUTH, WILLIAM W., CHATHAM, W. WINN
Format: Artigo
Idioma:Inglês
Publicat: 2012
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350827/
https://ncbi.nlm.nih.gov/pubmed/22275291
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.34400
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