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The enzymatic activity of human aldehyde dehydrogenases 1A2 and 2 (ALDH1A2 and ALDH2) is detected by Aldefluor, inhibited by diethylaminobenzaldehyde and has significant effects on cell proliferation and drug resistance

There has been a new interest in using aldehyde dehydrogenase (ALDH) activity as one marker for stem cells since the Aldefluor flow cytometry-based assay has become available. Diethylaminobenzaldehyde (DEAB), used in the Aldeflour assay, has been considered a specific inhibitor for ALDH1A1 isoform....

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Detalhes bibliográficos
Main Authors: Moreb, Jan S., Ucar, Deniz, Han, Shuhong, Amory, John K., Goldstein, Alex S., Ostmark, Blanca, Chang, Lung-Ji
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3350780/
https://ncbi.nlm.nih.gov/pubmed/22079344
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cbi.2011.10.007
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