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An autoregulatory feedback loop between Mdm2 and SHP that fine tunes Mdm2 and SHP stability
Mdm2 is a crucial negative regulator of the tumor suppressor function of p53. However, little is known about Mdm2 protein stability regulation by other tumor suppressors. Nuclear receptor small heterodimer partner (SHP, NROB2) functions as a tumor suppressor in liver cancer. We show here a surprisin...
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| Hlavní autoři: | , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2012
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3350641/ https://ncbi.nlm.nih.gov/pubmed/22575647 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2012.03.022 |
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