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Biological influence of Hakai in cancer: a 10-year review
In order to metastasize, cancer cells must first detach from the primary tumor, migrate, invade through tissues, and attach to a second site. Hakai was discovered as an E3 ubiquitin-ligase that mediates the posttranslational downregulation of E-cadherin, a major component of adherens junctions in ep...
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| Hauptverfasser: | , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Springer US
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3350634/ https://ncbi.nlm.nih.gov/pubmed/22349934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10555-012-9348-x |
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