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In silico identification of novel lead compounds with AT(1 )receptor antagonist activity: successful application of chemical database screening protocol
BACKGROUND: AT(1 )receptor antagonists are clinically effective drugs for the treatment of hypertension, cardiovascular, and related disorders. In an attempt to identify new AT(1 )receptor antagonists, a pharmacophore-based virtual screening protocol was applied. The pharmacophore models were genera...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3349973/ https://ncbi.nlm.nih.gov/pubmed/22380004 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/2191-2858-2-7 |
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