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IFN-γ–Driven IDO Production from Macrophages Protects IL-4Rα–Deficient Mice against Lethality during Schistosoma mansoni Infection

The balance between alternatively activated macrophages (AAMs)/M2 cells and classically activated macrophages (M1 cells) is largely dependent on the effects of IL-4 and interferon (IFN)-γ, respectively. Although AAM/M2 cells can suppress inflammation and repair damaged tissue, M1 cells produce an ar...

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Autors principals: Rani, Reena, Jordan, Michael B., Divanovic, Senad, Herbert, De'Broski R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Investigative Pathology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349826/
https://ncbi.nlm.nih.gov/pubmed/22426339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2012.01.013
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