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Phase I trial of tremelimumab in combination with short-term androgen deprivation in patients with PSA-recurrent prostate cancer

CTLA-4 blockade has demonstrated antitumor efficacy in human clinical trials. The antitumor mechanism is presumably mediated in part by the expansion of tumor-specific T cells. Androgen deprivation, the cornerstone of treatment for patients with metastatic prostate cancer, has been shown to elicit p...

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Autors principals: McNeel, Douglas G., Smith, Heath A., Eickhoff, Jens C., Lang, Joshua M., Staab, Mary Jane, Wilding, George, Liu, Glenn
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349783/
https://ncbi.nlm.nih.gov/pubmed/22210552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-011-1193-1
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