IGFBP3 impedes aggressive growth of pediatric liver cancer and is epigenetically silenced in vascular invasive and metastatic tumors

BACKGROUND: Hepatoblastoma (HB) is an embryonal liver neoplasm of early childhood with a poor prognosis for patients with distant metastases and vascular invasion. We and others have previously shown that the overexpression of insulin-like growth factor 2 (IGF2), loss of imprinting at the IGF2/H19 l...

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Detalhes bibliográficos
Main Authors: Regel, Ivonne, Eichenmüller, Melanie, Joppien, Saskia, Liebl, Johanna, Häberle, Beate, Müller-Höcker, Josef, Vollmar, Angelika, von Schweinitz, Dietrich, Kappler, Roland
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349592/
https://ncbi.nlm.nih.gov/pubmed/22401581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-11-9
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