Construction of Bordetella pertussis strains with enhanced production of genetically-inactivated Pertussis Toxin and Pertactin by unmarked allelic exchange

BACKGROUND: Acellular Pertussis vaccines against whooping cough caused by Bordetella pertussis present a much-improved safety profile compared to the original vaccine of killed whole cells. The principal antigen of acellular Pertussis vaccine, Pertussis Toxin (PT), must be chemically inactivated to...

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Bibliographic Details
Main Authors: Buasri, Wasin, Impoolsup, Attawut, Boonchird, Chuenchit, Luengchaichawange, Anocha, Prompiboon, Pannipa, Petre, Jean, Panbangred, Watanalai
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349578/
https://ncbi.nlm.nih.gov/pubmed/22524455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2180-12-61
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