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Simplification of biochemical models: a general approach based on the analysis of the impact of individual species and reactions on the systems dynamics

BACKGROUND: Given the complex mechanisms underlying biochemical processes systems biology researchers tend to build ever increasing computational models. However, dealing with complex systems entails a variety of problems, e.g. difficult intuitive understanding, variety of time scales or non-identif...

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Bibliografski detalji
Glavni autori: Surovtsova, Irina, Simus, Natalia, Hübner, Katrin, Sahle, Sven, Kummer, Ursula
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349553/
https://ncbi.nlm.nih.gov/pubmed/22390191
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1752-0509-6-14
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