The tumour metabolism inhibitors GSAO and PENAO react with cysteines 57 and 257 of mitochondrial adenine nucleotide translocase

BACKGROUND: GSAO (4-(N-(S-glutathionylacetyl)amino) phenylarsonous acid) and PENAO (4-(N-(S-penicillaminylacetyl)amino) phenylarsonous acid) are tumour metabolism inhibitors that target adenine nucleotide translocase (ANT) of the inner-mitochondrial membrane. Both compounds are currently being trial...

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Detalhes bibliográficos
Main Authors: Park, Danielle, Chiu, Joyce, Perrone, Gabriel G, Dilda, Pierre J, Hogg, Philip J
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2012
Assuntos:
Primary Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3349534/
https://ncbi.nlm.nih.gov/pubmed/22448968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-12-11
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